Mounjaro in Primary Care Update

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Dear Valued Patient,

We are awaiting further information from commissioning organisations regarding tirzepatide (Mounjaro) being available from Primary Care Settings.  Please keep a check on our website or social media pages.  We would ask for your support and await further information before contacting the Practice about this, as we are not able to support you until we receive further information regarding the process for accessing this medication. 

We understand that many of our patients are exploring or currently using Mounjaro (tirzepatide) as part of their treatment for type 2 diabetes or for weight management. As with any medication, it’s important to understand how Mounjaro may interact with other treatments you are taking — especially hormone replacement therapy (HRT) and oral contraceptives.

How Mounjaro Works

Mounjaro slows down how quickly your stomach empties, which is part of how it helps control blood sugar and support weight loss. However, this effect may also impact the absorption of other oral medications, including hormonal therapies.

Interaction with Contraception

If you are taking oral contraceptives, Mounjaro may reduce their effectiveness, particularly in the days following an injection. This is due to the delayed gastric emptying, which can affect how well your body absorbs oral hormones.

Our recommendation:

  • Consider using an additional, non-oral form of contraception (e.g., condoms or an intrauterine device [IUD]) , implant or injection. 
  • If oral contraceptives are your only form of birth control, please speak with us or your prescribing provider to review safer alternatives or to assess your individual risk.

Interaction with Hormone Replacement Therapy (HRT)

If you are taking HRT in tablet form, Mounjaro may also alter how your body absorbs these hormones. This may potentially lead to changes in how effective your HRT is, or in the consistency of symptom relief.

Our recommendation:

  • If you are using oral HRT and notice any changes in your symptoms (e.g., return of hot flashes, mood changes), please let us know.
  • We may consider non-oral HRT options such as patches, gels, or sprays, which bypass the digestive system and are not affected by Mounjaro’s impact on stomach emptying.

What You Should Do

If you are using Munjaro please ask your provider how it will affect your contraception/ HRT or please ask us